**Core Concept**
Entamoeba histolytica is a protozoan parasite that causes amoebiasis, a disease characterized by intestinal infection and potential extraintestinal dissemination. The organism's virulence is largely attributed to its ability to invade and destroy human tissues, leading to symptoms such as dysentery and liver abscesses.

**Why the Correct Answer is Right**
Entamoeba histolytica is typically distinguished from its non-pathogenic counterpart, Entamoeba dispar, by its ability to invade and lyse human tissues. This is primarily due to the presence of a ventral disc and a prominent nucleus in E. histolytica, which allows it to attach to and penetrate the intestinal mucosa. The parasite's ability to secrete a proteolytic enzyme called cysteine proteinase also contributes to its pathogenicity.

**Why Each Wrong Option is Incorrect**
**Option A:** Entamoeba histolytica is indeed characterized by its ability to form cysts, which are a key feature of its life cycle and a diagnostic hallmark of the organism. Therefore, this option is incorrect.

**Option B:** E. histolytica is not typically associated with an amoeboid movement that is accompanied by the formation of a pseudopodium, as this is more characteristic of Amoeba proteus. However, E. histolytica does exhibit amoeboid movement, albeit in a more limited capacity.

**Option C:** E. histolytica is indeed capable of invading the intestinal mucosa and causing tissue destruction, which is a hallmark of its pathogenicity.

**Clinical Pearl / High-Yield Fact**
A key diagnostic feature of E. histolytica infection is the presence of cysts in the stool, which can be identified using a microscope or by PCR. It is essential to distinguish E. histolytica from its non-pathogenic counterpart, E. dispar, to guide appropriate treatment.

**Correct Answer: C.**