**Core Concept**
Crohn's disease is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation of the gastrointestinal tract, often involving the terminal ileum and proximal colon. The pathogenesis of Crohn's disease is complex, involving an interplay between genetic predisposition, environmental factors, and an abnormal immune response.

**Why the Correct Answer is Right**
Crohn's disease is associated with various extra-intestinal manifestations due to its systemic nature. These manifestations can include:
* Arthritis, particularly peripheral arthritis and sacroiliitis, due to the involvement of the axial skeleton and peripheral joints
* Dermatological manifestations, such as erythema nodosum and pyoderma gangrenosum
* Eye complications, including uveitis and conjunctivitis
* Hepatobiliary complications, including primary sclerosing cholangitis
* Osteoporosis and osteopenia due to malabsorption and inflammation
* Skin manifestations, such as psoriasis and dermatitis herpetiformis

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Crohn's disease is indeed associated with an increased risk of colon cancer, particularly in patients with a long-standing history of the disease.

**Option B:** This option is incorrect because Crohn's disease can cause a range of eye complications, including uveitis and conjunctivitis, due to the systemic nature of the disease.

**Option C:** This option is incorrect because Crohn's disease is associated with a range of skin manifestations, including erythema nodosum and pyoderma gangrenosum, due to the abnormal immune response.

**Clinical Pearl / High-Yield Fact**
It's essential to recognize that Crohn's disease is a systemic condition, and patients with Crohn's disease may present with a range of extra-intestinal manifestations, making a comprehensive evaluation and management plan crucial.

**Correct Answer: D.**