Which of the following is not associated with chorioamnionitis?
**Core Concept**
Chorioamnionitis is an inflammatory condition of the placenta and fetal membranes, typically caused by bacterial infection. It is a leading cause of preterm labor, fetal morbidity, and mortality. The condition is characterized by the release of inflammatory mediators, such as cytokines and prostaglandins, which can lead to fetal distress and other complications.
**Why the Correct Answer is Right**
Chorioamnionitis is often associated with symptoms such as maternal fever, uterine tenderness, and fetal tachycardia. The condition is typically caused by bacteria such as Group B Streptococcus, E. coli, and Bacteroides species, which can ascend from the vagina and cervix to the amniotic cavity. The inflammatory response in chorioamnionitis can also lead to the release of prostaglandins, which can stimulate uterine contractions and lead to preterm labor.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because chorioamnionitis is often associated with maternal fever and uterine tenderness, which are classic symptoms of the condition.
**Option B:** This option is incorrect because chorioamnionitis is a leading cause of preterm labor and fetal morbidity, making it a significant risk factor for stillbirth and neonatal mortality.
**Option C:** This option is incorrect because chorioamnionitis is often caused by bacterial infection, and the condition can lead to the release of inflammatory mediators such as cytokines and prostaglandins.
**Clinical Pearl / High-Yield Fact**
Chorioamnionitis is a medical emergency that requires prompt recognition and treatment to prevent fetal morbidity and mortality. The condition is often associated with maternal fever, uterine tenderness, and fetal tachycardia, and treatment typically involves antibiotics and delivery of the fetus.
**Correct Answer: D.**