Which of the following is not an intermediate of citric cycle?
Correct Answer: Acetyl-CoA
Description: The citric acid cycle - also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle - is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate. In addition, the cycle provides precursors of ceain amino acids as well as the reducing agent NADH that is used in numerous other biochemical reactions. Its central impoance to many biochemical pathways suggests that it was one of the earliest established components of cellular metabolism and may have originated abiogenically. The name of this metabolic pathway is derived from citric acid (a type of tricarboxylic acid) that is consumed and then regenerated by this sequence of reactions to complete the cycle. In addition, the cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, and produces carbon dioxide as a waste byproduct. The NADH generated by the TCA cycle is fed into the oxidative phosphorylation (electron transpo) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP.Ref: DM Vasudevan, 7th edition, page no: 245
Category:
Biochemistry
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