Which of the following is not an established antimicrobial drug synergism at clinical level?

A. Amphotericin B and flucytosine in cryptococcal meningitis

B. Carbenicillin and gentamicin in pseudomonal infections

C. Penicillin and tetracycline in bacterial meningitis

D. Trimethoprim and sulfamethoxazole in coliform infections

Correct Answer: Penicillin and tetracycline in bacterial meningitis

Description: Combination of a bacteriostatic and a bactericidal drug in most cases is antagonistic. Bactericidal drugs act on fast multiplying organisms whereas bacteriostatic drugs inhibit the growth. Here, penicillins are bactericidal whereas tetracyclines are bacteriostatic.

Category: Pharmacology

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