MECHANISMS OF AGING Theory Principle DNA & Genetic Theory -Aging is predetermined by genetic programmng. Neuroendocrine Theory -Loss of hypothalamic regulation and cell sensitivity to ormones. Free Radical Theory Cellular damage by production of metabolic free adicals. Membrane Theory -Decline in cell efficiency loss of lipid in cell membane. Hayflick Limit Theory Limitation of cell division. Mitochondial Decline Theory -Dysfunction of mitochondria in cells. Cross-Linking Theory Impairment of protein functions glycosylation. ref : robbins 10th ed