Pathology Which of the following is not a feature of sickle cell disease? A Autosplenectomy B Heterozygous individuals are at increased risk of Plasmodium falciparum infection C Ischemic tissue damage D Hydroxyurea is used as a therapeutic agent 💡 Explanation Which of the following is not a feature of sickle cell disease? ✓ Correct Answer: B. Heterozygous individuals are at increased risk of Plasmodium falciparum infection