**Question:** Which of the following is known to cause Pedal Botryomycosis?

A. Rhinosporidiosis
B. Microsporum canis
C. Histoplasmosis
D. Blastomycosis

**Core Concept:** Pedal botryomycosis is a fungal infection of the skin caused by bacteria or fungi. It is primarily seen in immunocompromised patients or in those with traumatic wounds.

**Why the Correct Answer is Right:** Microsporum canis is a fungus that belongs to the class of fungi called dermatophytes. Dermatophytes are responsible for causing various fungal infections, including ringworm, tinea corporis, and tinea cruris. In the case of pedal botryomycosis, the fungal spores of Microsporum canis can invade the skin and cause an infection, leading to the characteristic "grape-like" lesions seen in botryomycosis.

**Why Each Wrong Option is Incorrect:**

B. Rhinosporidiosis (A) is a chronic granulomatous infection caused by the fungus Rhinosporidium seeberi. It primarily affects the nasal cavity but is not typically associated with skin manifestations.

C. Histoplasmosis (D) is a pulmonary infection caused by Histoplasma capsulatum. It is not known to cause skin infections, including pedal botryomycosis.

D. Blastomycosis (D) is a pulmonary and disseminated infection caused by Blastomyces dermatitidis or Blastomyces caribbensis. It is not typically associated with skin manifestations, let alone pedal botryomycosis.

**Clinical Pearl:** Pedal botryomycosis is a rare skin infection caused by bacteria or fungi. In the case of Microsporum canis, it is essential to differentiate it from other skin infections like tinea corporis and tinea cruris. A thorough clinical history, physical examination, and appropriate investigations would help in making the correct diagnosis and initiating appropriate treatment.