Which of the following is indicated by the pedigree given below?
**Core Concept**
Autosomal Dominant Inheritance is characterized by the presence of the disease in every generation, with each child having a 50% chance of inheriting the disease-causing allele. This pattern is often seen in conditions such as Huntington's disease, Marfan syndrome, and achondroplasia.
**Why the Correct Answer is Right**
The pedigree shows a family with multiple generations affected by the disease, with each generation having an equal chance of being affected. This is a classic example of Autosomal Dominant Inheritance, where a single copy of the disease-causing allele is sufficient to cause the disease. The presence of affected individuals in every generation, with skipped generations, further supports this pattern.
**Why Each Wrong Option is Incorrect**
**Option A:** This pedigree does not show a clear pattern of inheritance, making it difficult to determine the mode of inheritance.
**Option B:** This pedigree is more consistent with X-linked Dominant Inheritance, where males are more frequently affected than females.
**Option C:** This pedigree is more consistent with X-linked Recessive Inheritance, where females are more frequently affected than males.
**Clinical Pearl / High-Yield Fact**
In Autosomal Dominant Inheritance, the disease-causing allele is present in every generation, but not necessarily expressed, making it essential to look for other affected family members to confirm the diagnosis.
**Correct Answer:** C.