**Core Concept**
Hemophilia A, also known as classic hemophilia, is a genetic disorder caused by a deficiency in factor VIII, a clotting factor essential for blood coagulation. This deficiency leads to prolonged bleeding and increased risk of bleeding complications.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of hemophilia A. Factor VIII is a crucial protein in the coagulation cascade, and its deficiency results in the inability to form a stable blood clot. This leads to increased levels of certain clotting factors and markers of coagulation activation, such as D-dimer and fibrin degradation products. Specifically, the level of von Willebrand factor (VWF), which is a carrier protein for factor VIII, is often elevated in hemophilia A patients.
**Why Each Wrong Option is Incorrect**
* **Option A:** Factor VII is not directly related to hemophilia A, as it is a separate clotting factor with a different deficiency leading to hemophilia B (Christmas disease).
* **Option B:** Prothrombin time (PT) is a test used to evaluate the extrinsic and common coagulation pathways, but it is not specifically increased in hemophilia A.
* **Option C:** Fibrinogen levels are often normal in hemophilia A patients, as the problem lies in the activation of coagulation factors rather than their production.
**Clinical Pearl / High-Yield Fact**
In hemophilia A patients, the level of von Willebrand factor (VWF) is often elevated, making it a useful marker for diagnosis. However, it's essential to note that VWF can also be elevated in other conditions, such as von Willebrand disease.
**Correct Answer:** C.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.