Which of the following is false regarding Multiple Sclerosis (MS)?

A. More common in women and age of onset is between 20-40 years of age

B. Risk factors include vitamin D deficiency and cigarette smoking

C. Pathological hallmark is axonal degeneration

D. HLA DRB1 in MHC class II is associated with 10% of disease risk

Correct Answer: Pathological hallmark is axonal degeneration

Description: Multiple sclerosis is an auto immune disease of central neural system with a relapsing and remitting or progressive course. The pathologic hallmark of disease is demyelination. Myelin specific antibodies are present on degenerating myelin sheaths. Surviving oligodendrocytes paially remyelinate surviving axons, which are called as shadow plaques. Reference: Harrison's Principles of Internal Medicine, 21st edition, p2661

Category: Medicine

Share:

← Previous MCQ

Next MCQ →

Get More

Subject Mock Tests

Practice with over 200,000 questions from various medical subjects and improve your knowledge.

Attempt a mock test now

Mock Exam

Take an exam with 100 random questions selected from all subjects to test your knowledge.

Coming Soon

Get More

Subject Mock Tests

Try practicing mock tests with over 200,000 questions from various medical subjects.

Attempt a mock test now

Mock Exam

Attempt an exam of 100 questions randomly chosen from all subjects.

Coming Soon