Which of the following is CD 15 & CD30 positive:
**Core Concept**
The question is testing the student's knowledge of immunophenotyping in hematopathology, specifically the expression of **CD markers** on the surface of certain lymphoma cells. **CD15** and **CD30** are significant markers used in the diagnosis of particular types of lymphomas.
**Why the Correct Answer is Right**
The correct answer is related to Hodgkin lymphoma, particularly the **classical Hodgkin lymphoma** subtype, which is known for expressing **CD15** and **CD30**. These markers are crucial for the diagnosis of this condition, as they are typically positive in the Reed-Sternberg cells, which are the malignant cells characteristic of Hodgkin lymphoma.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it does not typically express both **CD15** and **CD30**.
**Option B:** Incorrect as it usually lacks these specific markers.
**Option C:** Incorrect because, although it may express some lymphoid markers, **CD15** and **CD30** positivity is not characteristic.
**Option D:** This option is the correct answer and will be discussed in the correct answer line.
**Clinical Pearl / High-Yield Fact**
Remembering that **CD15** and **CD30** positivity is a hallmark of **classical Hodgkin lymphoma** is crucial for diagnosis. This helps in distinguishing it from other types of lymphoma.
**Correct Answer:** D. Hodgkin lymphoma.