Which of the following is associated with PAS positive macrophages?
Correct Answer: Whipple disease
Description: Ref. Robbins Pathology. 9th edition. Page. 791
Whipple disease:
Rare systemic infection due to Tropheryma whippelii, a gram positive intracellular actinomycete
Usually affects proximal intestine, mesenteric lymph nodes
Also called intestinal lipodystrophy
Symptoms:
Malabsorption with diarrhea, weight loss, abdominal pain
Occasionally polyarthritis, CNS complaints, lymphadenopathy, hyperpigmentation
Cardiac involvement less common
Microscopy
Distended macrophages in lamina propria containing PAS+ (diastase resistant) granules and rod shaped bacilli by EM
Dilated lymphatics or fat vacuoles
Category:
Unknown
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