Which of the following is amylin analogue-
**Core Concept**
Amylin analogues are a class of medications used in the treatment of diabetes mellitus. They are designed to mimic the action of amylin, a hormone co-secreted with insulin from the pancreas. Amylin analogues help to regulate blood glucose levels by inhibiting postprandial glucagon secretion, delaying gastric emptying, and reducing appetite.
**Why the Correct Answer is Right**
Pramlintide is an amylin analogue that is administered via subcutaneous injection. It works by binding to the amylin receptor on the surface of pancreatic beta cells, thereby inhibiting glucagon secretion and slowing gastric emptying. This leads to a reduction in postprandial glucose levels and an improvement in glycemic control. Pramlintide has a rapid onset of action and a duration of effect that lasts for several hours.
**Why Each Wrong Option is Incorrect**
* **Option A:** Exenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist, not an amylin analogue. It is used to improve glycemic control in patients with type 2 diabetes.
* **Option B:** Liraglutide is another GLP-1 receptor agonist, which is used for the treatment of type 2 diabetes and obesity. It has a different mechanism of action compared to amylin analogues.
* **Option D:** Insulin is a hormone that regulates blood glucose levels, but it is not an amylin analogue. Amylin analogues are used to complement insulin therapy and provide additional benefits in terms of glycemic control.
**Clinical Pearl / High-Yield Fact**
Amylin analogues should be used with caution in patients with a history of pancreatitis or thyroid C-cell tumors. They can also cause hypoglycemia, especially when used in combination with insulin or other glucose-lowering medications.
**Correct Answer: C. Pramlintide**