Which of the following is a TRUE statement regarding leukemia?
Correct Answer: ALL has got poor prognosis in children < lyr of age
Description: Factors associated with poor prognosis in a case of ALL are : children less than 1 years with t(4:11) translocation and patients with t(9:22). Factors associated with a orable prognosis in ALL are : children aged between 1-9 years of age with diagnostic WBC count less than 50,000/microl, rapid response to induction treatment, patients whose blasts are hyperdiploid, with trisomies of chromosomes 4, 10 and 17 and patients whose blasts have a t(12:21) and TEL-AML1 rearrangement . CLL is a disease of elderly usually seen after 50 years of age, and median age of presentation is 70 years. CML is a neoplasm of middle aged with median age of presentation being 55 years. Hairy cell leukemia is a B cell neoplasm of middle aged men with a median age of presentation being 55 years.
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