**Core Concept**
Protein C is a vitamin K-dependent serine protease that plays a crucial role in the regulation of blood coagulation by inactivating coagulation factors Va and VIIIa. Protein C analogues are synthetic molecules designed to mimic its anticoagulant properties.
**Why the Correct Answer is Right**
The correct answer is a protein C analogue that works by activating protein C, which then inactivates coagulation factors Va and VIIIa, leading to a decrease in thrombin generation and clot formation. This process is mediated through the protein C receptor (EPCR) and the thrombomodulin-protein C pathway. The protein C analogue mimics the activity of protein C, thereby providing anticoagulant effects.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not have any known anticoagulant properties or relation to protein C.
**Option B:** This option is incorrect as it is actually a protein S analogue, not a protein C analogue.
**Option C:** This option is incorrect as it is a different class of anticoagulant that works through a different mechanism.
**Clinical Pearl / High-Yield Fact**
Protein C analogues are used in patients with hereditary protein C deficiency to prevent venous thromboembolism. They are also being investigated for use in patients with sepsis and other conditions characterized by excessive coagulation.
**Correct Answer: C. A protein C analogue that works by activating protein C, thereby inactivating coagulation factors Va and VIIIa.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.