Which of the following is a procoagulation protein ?
Correct Answer: Thrombin
Description: Ans. is 'd' i.e., Thrombin Coagulation Cascade o Coagulation cascade is a series of enzymatic conversions, turning inactive proenzymes into activated enzymes and culminating the formation of thrombin. o Thrombin then conves the soluble protein fibrinogen precursor into insoluble fibrous protein fibrin. o The blood coagulation pathway are divided into. 1.Extrinsic --> Activated by tissue factor. 2.Intrinsic --> Activated by factor XII (Hagmen factor). o In vivo coagulation is predominantly occurs extrinsic pathway. o Clotting is regulated by three types of natural anticoagulants. Antithrombin III --> Binds to heparin like molecule on endothelial surface and this complex inhibit factor II (thrombin), IX, X, XI, XIL Protein 'C' & 'S' --> These are Vit K dependent proteins. Thrombomodulin bind to thrombin and this complex activates protein 'C', which then, with the help of protein `S' as a cofactor, inactivates factor V & VIII. Tissue factor pathway --> Secreted by endothelium and inactivates tissue factor VII & factor X. inhibitor ( TFPI)
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now