Which of the following is a non-invasive test used to diagnose fetal Rh genotype in Rh D alloimmunization?
Correct Answer: Cell free fetal DNA
Description: Fetal Rh D genotype assessment from maternal blood offers several potential benefits. Administration of anti-D immune globulin to an Rh D-negative pregnant woman carrying an Rh D-negative fetus can be eliminated.In the setting of Rh D alloimmunization, early identification of an Rh D-negative fetus can avoid unnecessary amniocentesis and/or serial fetal middle cerebral aery Doppler assessment. Rh D genotype evaluation using cell-free fetal DNA is done using real-time PCR to target multiple exons of the RHD gene(Ref: William's Obstetrics; 25th edition)
Category:
Gynaecology & Obstetrics
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