Which of the following is a major criterion for Neurofibromatosis (NF-1)?
Correct Answer: Axillary freckling
Description: Neurofibromatosis NF-1 gene on the proximal long arm of chromosome 17 AD NF-2 gene is located near centre of long arm of chromosome 22 Diagnostic criteria for NF 1: >=2 of the following criteria to be fulfilled: 1. >=6 cafe-au-lait macules of over 5mm in greatest diameter in pre pubeal individuals and over 15mm in greatest diameter in post pubeal individuals. 2. >=2 neurofibromas of any type or 1 plexiform neurofibroma. 3. Freckling in the axillary or inguinal regions 4. Optic glioma 5. >=2 Lisch nodules 6. Distinctive osseous lesion such as sphenoid dysplasia or thinning of the long bone coex with or without pseudoahrosis 7. A first-degree relative (parent, sibling, offspring) with NF1 by the above criteria. The presence of one or two cafe-au-lait macules is not diagnostic in the absence of other signs of the disease but if six or more cafe-au-lait macules are present, with a diameter of 5 mm or more, the probability of neurofibromatosis is high.
Category:
Dental
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now