Which of the following is a histological feature of Whipple’s disease?
Correct Answer: Macrophages with PAS (+) material inside the lamina propria
Description: Whipple's disease Hallmark - Presence of PAS +ve, diastase resistant granules inside foamy macrophages containing rod shaped bacilli. The presence of T. Whipplei outside macrophages is more impoant indicator of active disease than their presence inside the macrophages. Multisystem involvement: Joints (Early involvement) Intestine - Impaired lymphatic drainage resulting in malabsorption & diarrhea Lymph nodes CNS (Late involvement) Rx - Antibiotics
Category:
Pathology
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