Which of the following is a cause of intravascular hemolysis
Correct Answer: PNH
Description: PNH * Paroxysmal nocturnal hemoglobinura (PNH ) is an acquired intrinsic defect in RBC membrane * Its due to mutation in PIGA gene (phosphatidyl inositol glycan complementation group A) PNH red cell are deficient in :- * CD55 or decay accelerating factor * CD 59 or membrane inhibitor of reactive lysis * C8 binding protein * Characterised by pancytopenia, hemolysis and thrombosis * Diagnosed by FLOWCYTOMETRIC ANALYSIS * Thrombosis is the leading cause of disease related death Ref:- Robbins Basic Pathology 10th Edition; Pg num:- 642,643
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now