Which of the following insulin is rapidly acting?
**Core Concept**
Insulin is a hormone produced by the pancreas that regulates blood glucose levels. Rapid-acting insulin is a type of insulin that starts working within 15 minutes of injection, peaks within 1 hour, and has a relatively short duration of action.
**Why the Correct Answer is Right**
Rapid-acting insulin, such as Aspart (NovoLog), Lispro (Humalog), or Glulisine (Apidra), is designed to mimic the body's natural insulin response. These insulins are rapidly absorbed into the bloodstream after injection, allowing for quick action to lower blood glucose levels. They are often used to control blood glucose spikes after meals. The rapid onset and short duration of action of these insulins make them ideal for use in mealtime dosing.
**Why Each Wrong Option is Incorrect**
**Option A:** Regular insulin (Humulin R, Novolin R) is an intermediate-acting insulin that starts working within 30 minutes and peaks in 2-4 hours, making it slower than rapid-acting insulins.
**Option B:** NPH insulin (Humulin N, Novolin N) is an intermediate-acting insulin that starts working within 2-4 hours and peaks in 4-12 hours, making it even slower than regular insulin.
**Option C:** Ultralente insulin (Humulin U, Novolin U) is a long-acting insulin that starts working in 4-6 hours and can last up to 24 hours, making it the slowest of the options.
**Clinical Pearl / High-Yield Fact**
Rapid-acting insulin is often used in combination with long-acting insulin to provide a basal insulin background and mealtime insulin to control postprandial glucose spikes.
**Correct Answer: C. Ultralente insulin is a long-acting insulin that starts working in 4-6 hours and can last up to 24 hours, making it the slowest of the options.