G.I.P Secretion + glucose /fat in duodenum, in large doses it inhibits gastric secretion and motility V.I.P -They are inhibitory to the smooth muscles of the intestines. -It causes smooth muscle relaxation in the GIT --> decreases the motility Somatostatin: -Central mechanism of inhibition of gastric acid secretion. -No role in inhibition of gastric motility or gastric emptying Ghrelin: -Increases GH release from the pituitary. -Increases appetite by stimulating neuropeptide Y (NPY) in the feeding centers of the lateral hypothalamus. -Decreases the breakdown of fat and increases gastric motility and acid secretion. -Thus, ghrelin has effect on both gastric motility and secretion; it increases both.