Which of the following inhalational anesthetic agent is contraindicated in liver disease?
Correct Answer: Halothane
Description: Ans. b (Halothane). (Ref. Lee's synopsis of Anesthesia 12th ed. 163)Ether may cause a transient depression of liver function but does not cause significant damage.HALOTHANE# Dose: 0.5% (MAC 0.75%)# Actions: analgesic, anaesthetic# Advantages:- Potent and effective,- Allows for high FI02 delivery,- Bronchodilatation,- Low irritant,- Nice smell; can be used for induction# Disadvantages:- CVS depression,- Cerebral Vasodilatation- | ICP,- Respiratory depression, Airway irritation,- "halothane hepatitis",- Arrhythmias,- Myocardial depression,- Incidence of malignant hyperpyrexiaISOFLURANE# An isomer of enflurane.# It is a stable agent, so, no need of preservative.# It does not depress myocardium, so good for cardiac surgery.# Sensitizes heart to catecholamines, but not nephro/hepatotoxic.# Commonly used in neurosurgery.# Can cause coronary-steal syndrome.ENFLURANE# Nonirritating and noninflammable Liquid# Stimulates salivary and respiratory secretions slightly# Heart rate decreases little and reduction of cardiac output is less marked.# Does not sensitize the heart to adrenaline, arrhythmias are rare.# Bronchodilatation is similar to halothane.# It is a better skeletal muscle relaxant.# Contraindicated in epilepsy.METHOXYFLURANE# It has highest amount of fluoride content.# It can be converted into oxalate in the liver and can cause oxalate renal stone formation.# It is nephrotoxic and causes high out put renal failure.# Not used commonly.SEVOFLURANE# Induction and emergence from anaesthetic are fast and rapid changes in depth can be achieved.# Acceptability is good by pediatric patients.# Sevoflurane does not cause sympathetic stimulation and airway irritation even during rapid induction. Amount of fluoride liberated is safe for kidney and liver.# It is degraded by soda lime - not recommended for use in closed circuit.# Sevoflurane has rapid induction (1-2 min) and also emergence from anesthesia is more rapid than Isoflurane, and is comparable with than seen after continuous Propofol anesthesia. This makes it suitable for day -stay surgery.DESFLURANE# Anaesthetic for out patient surgery.# Induction and recovery are very fast.# Postanaesthetic cognitive and motor impairment is short-lived.# Desflurane is less potent than isoflurane; may induce coughing, breath holding and laryngospasm.# Desflurane can serve as a good alternative to isoflurane for routine surgery.
Category:
Anaesthesia
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now