Gynaecology & Obstetrics Which of the following (in maternal serum) indicate open neural tube defect: March 2011 A Increased folic acid levels B Increased Alpha fetoprotein levels C Decreased Alpha fetoprotein levels D Decreased beta-HCG 💡 Explanation Which of the following (in maternal serum) indicate open neural tube defect: March 2011 ✓ Correct Answer: B. Increased Alpha fetoprotein levels