Which of the following gene mutations can lead to idiopathic steroid resistant nephrotic syndrome?
Correct Answer: All of the above
Description: A number of proteins have been identified that are components of the cell membrane or actin cytoskeleton of the podocyte. These include nephrin (NPHS1), a-actinin-4, podocin (NPHS2), CD2AP, Wilms tumor suppressor (WT1), and TRPC6. Mutations in the genes for these proteins, occurring in autosomal dominant and recessive patterns, have been associated with steroid-resistant nephrotic syndrome and biopsy-proven FSGS. Ref: Gipson D.S., Trachtman H (2009). Chapter 25. Focal Segmental Glomerulosclerosis. In Lerma E.V., Berns J.S., Nissenson A.R. (Eds), CURRENT Diagnosis & Treatment: Nephrology & Hypeension.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now