Which of the following enzymes are responsible for generating ‘oxygen burst’ within neutrophils for killing intracellular bacteria?
Correct Answer: NADPH Oxidase
Description: The final step in the microbial killing is due to reactive oxygen species called respiratory burst The generation of the oxygen metabolites is due to rapid activation of a leukocyte NADPH oxidase, called the phagocyte oxidase, which oxidizes NADPH and, in the process, conves oxygen to superoxide ion (O2 * ) The reactive oxygen species thus produced are toxic to bacteria and help the phagocyte kill them once they are ingested. ref robbins basic pathology 9th ed page 38
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