Which of the following enzyme is a constituent of HMP shunt-
Correct Answer: G-6-P dehydrogenase
Description: Ans:C : G-6-P- dehydrogenase.The Hexose MonoPhosphate ShuntIt is also known as "Pentose phosphate Pathway" (PPP). This is alternative Glucose oxidation pathway. * Location: Cytoplasm of cells of the liver, adrenal coex, and lactating mammary glands.* Substrate: Glucose-6-phosphate.* Oxidative poion: Irreversible. Generates two NADPH, which can then be used in fatty acid synthesis and cholesterol synthesis and for maintaining reduced glutathione inside RBCs.* Nonoxidative poion: Reversible. Generates intermediate molecules (ribose-5-phosphate; glyceraldehyde-3-phosphate; fructose-6-phosphate) for nucleotide synthesis and glycolysis.* Regulation: Key enzyme in the pentose-phosphate pathway is glucose-6-phosphate dehydrogenase. Levels of glucose-6-phosphate dehydrogenase are increased in the liver and adipose tissue when large amounts ofcarbohydrates are consumed. Glucose-6-phosphate dehydrogenase is stimulated by NADP+ and inhibited by NADPH and by palmitoyl-CoA (pa of the fatty acid synthesis pathway).* Purpose: Functions as an alternative route for glucose oxidation that does not directly consume or produce ATP.
Category:
Biochemistry
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