Biochemistry Which of the following enzyme dysfunction leads to lactic acidosis in thiamine deficiency? A Pyruvate carboxylase B Phosphofructokinase C Phosphoenol pyruvate carboxykinase D Pyruvate dehydrogenase 💡 Explanation Which of the following enzyme dysfunction leads to lactic acidosis in thiamine deficiency? ✓ Correct Answer: D. Pyruvate dehydrogenase