Vasomotor Reversal Of Dale - Adrenaline has biphasic effect on blood pressure. - a1 - Strong receptor thus more effect. - b2 - Sensitive receptor thus stimulated at low dose too. When adrenaline is given IV at high doses 1st BP will increase due to stimulation of a1 > b2 & then BP will decrease due to b2 stimulation. When adrenaline is given IV at high dose with a blocker, exaggerated fall of BP occurs called as Vasomotor Reversal of Dale. In adrenaline producing pheochromocytoma, If person is treated by alpha blocker, then this phenomenon will occur and thus death can occur due to severe hypotension. Therefore alpha blocker is always combined with beta blocker in adrenaline producing tumor.