**Core Concept**
The question requires understanding of drugs that are effectively removed by dialysis, which is a process used to remove waste products and excess substances from the blood when the kidneys are not functioning properly. This concept is crucial in the management of patients with renal failure.
**Why the Correct Answer is Right**
The correct answer is a drug that has a small volume of distribution (Vd) and is not extensively bound to plasma proteins. Drugs with these properties can be effectively removed by dialysis. Examples of such drugs include lithium, iodine, and certain anticonvulsants like phenobarbital. Dialysis is effective in removing these drugs because they are not extensively metabolized and have a low concentration in tissues.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a drug that is extensively metabolized by the liver and has a large volume of distribution. As a result, it is not effectively removed by dialysis.
**Option B:** This option is incorrect because it is a drug that is highly bound to plasma proteins, making it less accessible to dialysis.
**Option C:** This option is incorrect because it is a drug that is primarily excreted by the kidneys, but it is not effectively removed by dialysis due to its large volume of distribution and extensive tissue binding.
**Clinical Pearl / High-Yield Fact**
A key factor in determining whether a drug should be removed by dialysis is its volume of distribution and plasma protein binding. Drugs with small volumes of distribution and low plasma protein binding are more likely to be effectively removed by dialysis.
**Correct Answer:** A.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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