Which of the following drugs can cause Torsades de pointes ?
**Core Concept**
Torsades de pointes is a rare but life-threatening form of abnormal heart rhythm, also known as a ventricular tachyarrhythmia. It is characterized by a long QT interval on an electrocardiogram (ECG) and can be caused by various factors, including medications that affect the heart's electrical activity.
**Why the Correct Answer is Right**
Drugs that prolong the QT interval can increase the risk of Torsades de pointes. This is because a prolonged QT interval can lead to abnormal electrical activity in the heart, causing the heart to beat too quickly or irregularly. Certain medications, such as antipsychotics, antidepressants, and antiarrhythmics, can prolong the QT interval by blocking potassium channels or affecting the heart's electrical activity.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not specify a drug that can cause Torsades de pointes. While some medications in this class may prolong the QT interval, the question is asking for a specific drug that can cause Torsades de pointes.
* **Option B:** This option is incorrect because it is a class of medications that can actually help to treat Torsades de pointes, rather than causing it.
* **Option D:** This option is incorrect because it is a medication that is not typically associated with QT interval prolongation or Torsades de pointes.
**Clinical Pearl / High-Yield Fact**
When prescribing medications that can prolong the QT interval, it's essential to monitor patients for signs of Torsades de pointes, such as palpitations, dizziness, or fainting. Patients with a history of heart disease, electrolyte imbalances, or other medical conditions may be at higher risk for developing Torsades de pointes.
**Correct Answer:** C.