Which of the following drug undergoes Hoffman’s elimination?
Correct Answer: Atracurium
Description: Ans. (A) Atracurium(Ref: KDT 8th/e p380)Atracurium and cis-atracurium undergo Hoffmann's elimination (spontaneous non-enzymatic molecular rearrangement) and are the agents of choice for patients with hepatic or renal insufficiency.Atracurium is metabolized to laudanosine that is responsible for seizures. Cis-atracurium is relatively safe in this regard.
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Pharmacology
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