Which of the following drug is metabolized by acetylation:
Correct Answer: Isoniazid
Description: Ans. (b) IsoniazidRef KDT 6th ed. / 25ACETYLATION* Compounds having amino or hydralazine residues are conjugated with the help of N-Acetyl transferase enzyme.# If acetylation is slow- its toxic# Fast acetylation- not effective or effectiveness decreases# Normal acetylation- effective* These drugs are remembered as SHIP drugs:# Sulfonamides (dapsone)# Hydralazine (anti HTN)# Isoniazid (anti TB)# Procainamide (anti-arrhythmic)* NOTE- phenytoin is an anti epileptic drug, which is always confused with procainamide in SHIP drugs. Phenytoin doesn't come under SHIP drugs.* Phenytoin hydroxylation in liver is carried out by cytochrome P 450.* SHIP drugs causes SLE.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now