Which of the following drug is given during pregnancy which result in the below abnormality in the fetus?
Correct Answer: Retinoic acid
Description: Ans. D. Retinoic acida. Acute retinoid toxicities may include mucocutaneous or laboratory abnormalities; bony changes may occur after chronic use at high dosesb. Mucocutaneous side effects may include cheilitis, xerosis, blepharon conjunctivitis, cutaneous photosensitivity, photophobia, myalgia, arthralgia, headaches, alopecia, nail fragility, and increased susceptibility to staphylococcal infectionsc. Some patients develop a "retinoid dermatitis" characterized by erythema, prupritus, and scaling,d. Pseudotumor cerebri, especially when systemic retinoids are combined with tetracyclines (tetracycline or minocycline; the mechanism for this adverse drug event is unknown),e. Diffuse idiopathic skeletal hyperostosis (DISH) syndrome, premature epiphyseal closure, and other skeletal abnormalitiesf. Systemic retinoids are highly teratogenic: -g. There is no safe dose during pregnancyh. Common malformations: Cleft lip cardiovascular, thymic, and central nervous system (CNS) abnormalities
Category:
Pharmacology
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