Which of the following drug has the least Marrow suppression
Correct Answer: Vincristine
Description: Mitotic Spindle Inhibitors:Vincristine binds to the tubulin dimer with the result that microtubules are disaggregated. This results in the block of growing cells in M-phaseVincristine is metabolized by the liver, and dose adjustment in the presence of hepatic dysfunction is required. It is a powerful vesicant, and infiltration can be treated by local heat and infiltration of hyaluronidase. At clinically used intravenous doses, neurotoxicity in the form of glove-and-stocking neuropathy is frequent. Acute neuropathic effects include jaw pain, paralytic ileus, urinary retention, and the syndrome of inappropriate antidiuretic hormone secretion. Myelosuppression is not seen.Reference: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 103e; Principles of Cancer treatment
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