Which of the following does not belong to dystrophin-glycoprotein complex
Correct Answer: Perlecan
Description: Perlecan is a large extracellular matrix proteoglycan that plays a crucial role in tissue development and organogenesis. Dystrophin-glycoprotein complex The dystrophin-glycoprotein complex provides a structural link between the cytoskeleton of the muscle cell and the extracellular matrix, which appears to stabilize the sarcolemma, adds strength to the muscle by providing a scaffolding for the fibrils and prevents contraction-induced injury(rupture). Organisation of DG complex Dystrophin connects F-actin to the transmembrane protein b-dystroglycan smaller proteins called syntrophins. This b-dystroglycan, in turn connects to the merosin subunit of laminin 211 in the extracellular matrix a-dystroglycan The dytroglycans are also associated with a complex of four transmembrane glycoproteins, a-,b-,g- and d- sarcoglycan and sarcospan. Ref: Ganong's Review of Medical physiology 25th edition Pgno: 103
Category:
Physiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now