Pharmacology Which of the following describes the first pass metabolism A Drug given IV accumulates quickly in the central nervous system (CNS). B Inactivation of a drug as a result of the gastric acids. C Absorption of a drug through the duodenum. D Drug given orally is metabolized by the liver before entering the circulation. 💡 Explanation Which of the following describes the first pass metabolism ✓ Correct Answer: D. Drug given orally is metabolized by the liver before entering the circulation.