Pharmacology Which of the following combinations can result in severe toxicity due to inhibition of cytochrome 450 enzymes? A Amiodarone + phenytoin B Carbamazepine + phenytoin C Atorvastatin + Itraconazole D Phenytoin + Rifampin 💡 Explanation Which of the following combinations can result in severe toxicity due to inhibition of cytochrome 450 enzymes? ✓ Correct Answer: C. Atorvastatin + Itraconazole