Which of the following chemokine is having CCR3 receptor?
**Core Concept**
The CCR3 receptor is a chemokine receptor that plays a crucial role in the recruitment of eosinophils and basophils to sites of inflammation. This receptor is involved in the pathogenesis of various allergic and inflammatory diseases.
**Why the Correct Answer is Right**
The CCR3 receptor is specifically activated by chemokines such as eotaxin (CCL11), eotaxin-2 (CCL24), and eotaxin-3 (CCL26), which are produced by various cell types, including epithelial cells and endothelial cells. The binding of these chemokines to the CCR3 receptor triggers a signaling cascade that leads to the activation of eosinophils and basophils, resulting in their migration to the site of inflammation. This process is essential for the development of allergic responses, such as asthma and atopic dermatitis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify the correct chemokine that binds to the CCR3 receptor. While it may be a chemokine, it is not the correct one associated with the CCR3 receptor.
**Option B:** This option is incorrect because it is a different chemokine receptor, CCR5, which is primarily involved in the recruitment of T cells and macrophages to sites of inflammation.
**Option C:** This option is incorrect because it is a chemokine receptor, CXCR3, which is primarily involved in the recruitment of T cells to sites of inflammation.
**Option D:** This option is incorrect because it is a different chemokine receptor, CCR7, which is primarily involved in the recruitment of T cells and dendritic cells to lymphoid organs.
**Clinical Pearl / High-Yield Fact**
The CCR3 receptor is a key player in the pathogenesis of allergic diseases, and its activation by chemokines such as eotaxin can lead to the recruitment of eosinophils and basophils to the airways, contributing to the development of asthma.
**Correct Answer:** C. Eotaxin (CCL11)