**Core Concept**
Cephalosporins are a class of beta-lactam antibiotics that can cause various side effects, including hematological abnormalities such as thrombocytopenia. This is often due to the inhibition of platelet production in the bone marrow.

**Why the Correct Answer is Right**
Thrombocytopenia associated with cephalosporins is usually a result of immune-mediated platelet destruction or inhibition of platelet production in the bone marrow. Some cephalosporins, such as cefamandole and cefoperazone, have been specifically linked to this adverse effect. These antibiotics can induce the production of antibodies against platelets, leading to their destruction.

**Why Each Wrong Option is Incorrect**
**Option A:** Ceftriaxone is a third-generation cephalosporin that is generally well-tolerated and not commonly associated with thrombocytopenia.
**Option B:** Cefepime is another third-generation cephalosporin that is not typically linked to hematological abnormalities.
**Option C:** Cefotaxime, a second-generation cephalosporin, can cause various side effects, but thrombocytopenia is not a common or well-documented adverse effect.

**Clinical Pearl / High-Yield Fact**
When prescribing cephalosporins, it is essential to monitor patients for signs of thrombocytopenia, particularly if they have a history of platelet disorders or are receiving other medications that may interact with cephalosporins.

**Correct Answer:** C. Cefoperazone