Which of the following can carry larger genome ?
## **Core Concept**
The question pertains to the characteristics of different viral vectors used in genetic engineering and gene therapy. Specifically, it tests the understanding of the genome size that various viral vectors can accommodate.
## **Why the Correct Answer is Right**
The correct answer, , refers to Adeno-associated virus (AAV). AAV is a small virus that belongs to the family Parvoviridae. One of the key features of AAV is its ability to carry a relatively larger genome compared to some other viral vectors like certain strains of , which typically have very limited packaging capacity. AAV can package and deliver DNA fragments of up to approximately 4.7 kilobases (kb) in size, making it suitable for many gene therapy applications.
## **Why Each Wrong Option is Incorrect**
- **Option A:** typically refers to a type of viral vector with limited genome size capacity, often much smaller than AAV, making it less suitable for carrying larger genomes.
- **Option B:** might refer to another type of viral vector, but without specific details, it's generally understood that some viral vectors have more limited capacities than AAV for genome size.
- **Option D:** , similar to option A, often represents viral vectors with constrained genome packaging capacities.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that AAV vectors are widely used in gene therapy due to their safety profile, ability to infect non-dividing cells, and relatively larger genome packaging capacity compared to some other vectors. This makes AAV a versatile tool for delivering therapeutic genes in various clinical applications.
## **Correct Answer:** .