Anaesthesia Which of the following best explains why Lignocaine has a higher fetal-to-maternal plasma ratio when compared with bupivacaine? A Bupivacaine has low molecular weight B Lignocaine has higher protein-binding C Bupivacaine has a lower dissociation constant (pKa) D Lignocaine is less protein bound 💡 Explanation Which of the following best explains why Lignocaine has a higher fetal-to-maternal plasma ratio when compared with bupivacaine? ✓ Correct Answer: D. Lignocaine is less protein bound