Which of the following best explains why Lignocaine has a higher fetal-to-maternal plasma ratio when compared with bupivacaine?

A. Bupivacaine has low molecular weight

B. Lignocaine has higher protein-binding

C. Bupivacaine has a lower dissociation constant (pKa)

D. Lignocaine is less protein bound

Correct Answer: Lignocaine is less protein bound

Description: Lignocaine is less protein bound than bupivacaine. Unbound form of drug thus easily gets transferred across placenta.

Category: Anaesthesia

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