Which of the following antiumor agents works by impairing de novo purine synthesis?
Correct Answer: Methotrexate (antifolate)
Description: Ans. is 'c' i.e., Methotrexate (antifolate) o Methotrexate and permetrexed are dihydrofolate reductase (DHF Rase) inhibitors. o These drug also inhibit thymidylate synthase and de novo purine synthesis, which contribute to methotrexate toxicity.
Category:
Pharmacology
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