Medical MCQ-Which of the following antimicrobial is effective against an organism producing extended spectrum beta lactamase?

Which of the following antimicrobial is effective against an organism producing extended spectrum beta lactamase?

Amoxicillin-Clavulinic acid

Cefepime

Piperacillin-Tazobactam

Ceftriaxone

Question Category:

Pharmacology

Correct Answer:

Piperacillin-Tazobactam

Description:

Ans. (C) Piperacillin-tazobactam(Ref: Harrison 18th/1247)Organisms producing ESBL-like Klebsiella are resistant to most beta-lactams except carbapenems.ESBL can be inhibited by beta lactamase inhibitors.Amoxicillin is not effective against Klebsiella whereas piperacillin has wide spectrum including Klesiella.

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