**Core Concept:** Many anticancer drugs are excreted by the kidneys and liver, but some may be excreted through other routes as well. Lungs can contribute to drug excretion via diffusion and secretion mechanisms.

**Why the Correct Answer is Right:** Drugs like Cisplatin, a platinum-based chemotherapy drug, undergo secretion by the lungs. In this case, the correct answer is **D**:

**Correct Answer: Cisplatin**

Cisplatin is a cytotoxic chemotherapy drug used to treat various types of cancer, including testicular, ovarian, and lung cancers. The primary mode of action involves forming intrastrand and interstrand DNA adducts, leading to DNA damage and cell death. The liver and kidneys help in the excretion of cisplatin, but it can also be secreted by the lungs through a process known as secretion. This mechanism allows the drug to be expelled from the body, preventing its accumulation and reducing toxicity.

**Why Each Wrong Option is Incorrect:**

**Option A:** Pemetrexed is an antineoplastic agent used for treating mesothelioma and non-small cell lung cancer. It is primarily excreted via the kidneys and does not involve lungs in excretion.

**Option B:** Gemcitabine is a nucleoside analog used in the treatment of various cancers, including pancreatic, lung, and breast cancers. It is primarily excreted via the kidneys and does not involve lungs in excretion.

**Option C:** Docetaxel is a taxane drug primarily used for treating breast, prostate, and lung cancers. It is primarily excreted via the kidneys and does not involve lungs in excretion.

**Clinical Pearl:** A thorough understanding of drug excretion pathways is essential for clinicians to anticipate and manage potential side effects, drug interactions, and ensure optimal therapeutic outcomes for patients. Monitoring renal and hepatic function is crucial when prescribing these medications to prevent toxicity and ensure efficient elimination from the body.