Which of the following anti neoplastic drug causes hepatotoxicity:
Correct Answer: 6- mercaptopurine
Description: Ans. (a) 6- mercaptopurineRef.: KDT 6th ed. / 820* 6 mercaptopurine (6-MP) is a purine analogue which is metabolized by xanthine oxidase* It is a competitive inhibitor of DNA.* Allopurinol is NOT given along with 6-MP because allopurinol inhibits xanthine oxidase enzyme, which leads to increased toxicity due to accumulation of xanthine.Anti-Neoplastic DrugsTheir Side EffectCyclophosphamide, ifosphamideHemorrhagic cystitisProcarbazineDisulfiram like reactionBleomycin, busulfanPulmonary fibrosisVincristine, vinblastinePeripheral neuropathyCisplatinOtotoxicity, Nephrotoxicity6Mercaptopurine, 6ThioguanineHepatotoxicityDoxorubicin, DaunorubicinCardiotoxic
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now