Medical MCQ-Which of the following actions are caused by 2-4-diinitrophenol?

Which of the following actions are caused by 2-4-diinitrophenol?

Inhibition of ATP synthase

Inhibition of electron transpo

Uncoupling of oxidation and phosphorylation

Accumulation of ATP

Question Category:

Biochemistry

Correct Answer:

Uncoupling of oxidation and phosphorylation

Description:

2,4-dinitrophenol and valinomycin are two uncouplers which inhibit oxidative phosphorylation. 2,4-dinitrophenol is a potent uncoupler even in low concentrations by dissolving itself in the bi-lipid core of the inner cell membrane. Ref: Harper's Illustrated Biochemistry 27th/107; Biochemistry 3E By S C Rastogi, 2010, Page 224.

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