Which of following techniques tests is not used for detection of specific aneuploidy –
Correct Answer: Microarray
Description: FISH (Fluorescent in situ hybridisation) and PCR (polymerase chain reaction) like RT-PCR and QF PCR tests can detect specific aneuploidy.
Whereas, microarray-based CGH (comparative genomic hybridization) test can be used as high-resolution whole-genome scan for the detection or screening of unknown (non-specific) abnormalities, mutation or genomic imbalance including deletions, duplication and aneuploidies. Microarray-based CGH cannot detect balanced translocations or inversions.
So FISH and PCR can detect specific (known) chromosomal abnormalities whereas microarray-based CGH is better suited for screening unknown (non-specific) chromosomal abnormalities.
Category:
Biochemistry
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