**Core Concept**
* H. pylori is a Gram-negative, microaerophilic bacterium that colonizes the gastric mucosa, causing chronic gastritis, peptic ulcer disease, and gastric cancer.
* The bacterium's virulence factors, including the cag pathogenicity island, play a crucial role in its pathogenicity.
**Why the Correct Answer is Right**
* H. pylori infection is primarily transmitted through fecal-oral or oral-oral routes, with a significant association with poor sanitation, overcrowding, and socioeconomic status.
* The bacterium adheres to the gastric mucosa via its adhesin proteins, such as BabA and AlpA, which interact with host gastric epithelial cells.
* H. pylori infection induces chronic inflammation, leading to gastric atrophy, metaplasia, and eventually, gastric cancer.
**Why Each Wrong Option is Incorrect**
* **Option A:** H. pylori is not a cause of diarrhea. The bacterium primarily causes gastric and duodenal ulcers, gastritis, and gastric cancer.
* **Option B:** H. pylori is not a cause of liver disease. However, it can lead to liver enzyme elevation due to the systemic inflammatory response.
* **Option D:** This option is incomplete. Please provide the full text for a complete explanation.
**Clinical Pearl / High-Yield Fact**
* H. pylori infection is a significant risk factor for gastric cancer, and eradication of the bacterium can reduce the risk of gastric cancer development.
**Correct Answer:** A. H. pylori is not a cause of diarrhea.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.